Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome. If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. This site complies with the HONcode standard for trustworthy health information: verify here. Its also important to talk to your provider: Seek emergency medical care if you develop symptoms of deep vein thrombosis or a pulmonary embolism. News-Medical, viewed 04 March 2023, https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. U.S. National Institutes of Health, National Library of Medicine. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. High-Protein Diets -- Do They Really Work? Leg wraps that inflate and deflate to keep blood moving in your legs. Talk to your provider to see if you should be taking a blood thinner. Deep vein thrombosis and pulmonary embolism. There are 2 copies for Factor V gene, which are passed down from our parents. Make a donation. Pruthi RK (expert opinion). Fortunately, about 95 percent of people with this condition never develop a clot, according to the National Institutes of Health. Avoid foods high in vitamin k (leafy greens mostly), certain supplements, and avoid consuming too much alcohol. Factors that increase this risk include: Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). Recurrent fetal loss during the second or third trimester suggests an inherited thrombophilia or antiphospholipid antibody. Diets ideal for this include the Mediterranean diet and the DASH diet. ABSTRACT: Factor V Leiden thrombophilia is a genetic disorder that may increase a patient's risk of developing a venous thromboembolism (VTE). Factor V is a protein or clotting factor that helps create the enzyme reactions that form the fibrin in the clot. As a result, your blood may clot more easily than it should, leading to serious complications. Will Eating More Protein Help Your Body Gain Muscle Faster? Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). Your body has many different proteins that do this work. Two components of the plan, lower GI foods and smaller, more frequent meals, are both known to keep the blood sugar at a lower level, but the amount of carbohydrates would have to be tailored to your own diabetes treatment plan. However, it is often advised to avoid foods high in Vitamin K. Below is a list of foods that should be avoided because of their . Cranberry juice and other cranberry products can alter the effects of anticoagulants. Does my factor V Leiden need to be treated? Vegetarians and vegans: You can easily modify the 5-Factor Diet for vegetarian and vegan diets, though the protein sources for vegans are somewhat limited. . 0000003297 00000 n Complex carbohydrates (vegetables, sweet potato, wild rice, beans, lentils, oatmeal, quinoa). On a long flight, take regular walks down the aisles of the plane. This caution also extends to drug-food interactions. Kaushansky K, et al., eds. (accessed March 04, 2023). Should people with Factor V Leiden avoid Vitamin K? At least 1 of the genes that you inherited is the mutated gene that makes the Factor V Leiden protein. The need (or not) to wear graded elastic compression stockings during long-haul flights and long road trips. pph~~&"V: 9EP. However, some people with this disorder develop DVT or PE. Just by eliminating junk food, simple carbs, and high-calorie drinks, as in the 5-Factor Diet, most people are likely to see a dip on the scale. Direct oral anticoagulants (DOACs) are expected to replace VKAs because of their increased safety margin. It is important to note that alcohol also has some anticoagulant action and can protect adults from blood clots, although it is not recommended as a preventative measure for this purpose. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Ask your provider for resources to, Limit alcohol intake, and avoid it during long flights (it can lead to, Move around more. But if you have a blood clotting disorder, your blood forms clots more easily than normal. The mutation in itself is not a reason to avoid donating blood, but you should not give blood if you are using an anticoagulant (blood thinner). Last reviewed by a Cleveland Clinic medical professional on 09/28/2021. Most people with this disorder never develop a blood clot. Interactions which affect the efficacy of VKAs may result in bleeding from over-anticoagulation, or thrombosis due to under-anticoagulation. 0000008374 00000 n The best diet to follow is one full of foods that support heart health, because these are also naturally good for your blood health. The majority of people born with this mutation will not develop an abnormal blood clot in their lifetime. Does It Allow for Dietary Restrictions or Preferences? Factor V Leiden - Diagnosis and treatment - Mayo Clinic If you have factor V Leiden, there are other ways you can help reduce your risk of developing a blood clot beyond your diet. But if you do develop clots, be assured there are treatments that can help. This type of medicine usually isn't needed for people who have the factor V Leiden mutation but who have not experienced abnormal blood clots. 0000002579 00000 n Becoming a Vegetarian: Foods to Choose From. Can the results of the test affect my ability to obtain health insurance? Exercise: Required. If you cant walk around, flex your ankles and point your toes up and down. Papillophlebitis Associated With Coexisting Heterozygous Mutations of The 5-Factor Diet is a bundled diet and exercise plan that may help you lose weight and become more active. You may have a higher risk of getting: Pulmonary embolism. 0000001362 00000 n Depending on the severity of symptoms, other treatments may be necessary as well. No foods can change your genetics, but having the right type of diet may prevent your condition from getting worse. Where's the Beef? Accessed June 4, 2018. xref Healthy fats: Eat healthy fats each day such as olive oil, nuts, seeds and avocado. Accessed June 4, 2018. As such, daily intake or extra supplementation with vitamin K is typically unnecessary to keep body stores at healthy levels. 5. If you have an inactive (sedentary) lifestyle, consider how you could gradually increase your physical activity at home, school, work or play. Are young and healthy when you get a clot. We inherit one gene from our mother and one from our father. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. However, you can reduce your risk of a deep vein thrombosis or pulmonary embolism if you: The majority of people who have the prothrombin gene mutation dont get a dangerous blood clot and the mutation doesnt cause deep vein thrombosis or pulmonary embolism in the vast majority of pregnancies. The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. Medications can also work differently if they are taken on an empty stomach. Effective measures to eliminate or reduce other risk factors for DVT or PE, such as smoking cessation, weight loss and having a more active lifestyle. You may substitute gluten-free alternatives as long as they are low-sugar. However, your doctor might suggest that you take extra precautions to prevent blood clots if you have the factor V Leiden mutation and are going to have surgery. Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater . 0000002967 00000 n 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://medlineplus.gov/genetics/condition/prothrombin-thrombophilia/#resources). Wear compression stockings if your provider prescribes them for you. The Association Between MTHFR C677T Gene Polymorphism and Repeated Learn more about symptoms, risk factors, causes, diagnosis, treatment, complications, and outlook . Everyone is born with two copies of the factor V pronounced factor five gene. INR values of between 2.0 and 3.0 are considered effective therapeutic values while on anticoagulant therapy. As a result, clotting goes on longer than usual. If you notice any of these problems, call your doctor right away. Thick blood: Causes, risk factors, symptoms, and treatment Pruthi RK (expert opinion). trailer I WAS DIAGNOSED IN MARCH OF THIS YEAR AFTER HAVING MY 2ND PULMONARY EMBOLISM. Kaushansky K, et al., eds. startxref What are my risks? Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. In: Williams Hematology. In: Williams Hematology. Study Results Demonstrate VTE Treatment Satisfaction Among Patients, Managing Anticoagulants Before, During, and After Medical Procedures, Helping Women Make Choices About Contraception Following DVT Blood Clots, Panel Discussion: Blood Clots & Womens Health, Frequently Asked Questions: COVID-19 and Blood Clotting, Stop the Clot, Spread the Word Hospitalization, Toolkit for Knee and Hip Replacement Patients, Health Disparities and the VTE Mississippi Initiative, Atrial Fibrillation (AFib) and Clot-Provoked Stroke, Questions to Ask Your Doctor After Having a Blood Clot, NBCA Atrial Fibrillation Awareness Survey, Impact of Blood Clots in the Black Community Research Opportunities, NBCA Sports & Wellness Institute: Team Stop the Clot, Council of Emerging Researchers in Thrombosis (CERT), Medical & Scientific Advisory Board (MASAB), not enough clotting power leads to bleeding problems, too much clotting power can lead to the formation of dangerous blood clots. About 1 of every 250 Black people in America has the prothrombin gene mutation. Others can be life-threatening. No, you cant prevent this blood clotting disorder.
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